GTP酶是GTP/GDP结合蛋白。被细胞表面受体(GPCR)后, 它能调节下游效应器的功能。它可以结合GTP、水解GTP，因此在的GTP结合状态和非的GDP结合状态之间切换。它具有内在的GTP酶活性，可将GTP水解为GDP，从而使G蛋白失活。我们精心筛选的小鼠单抗体能捕捉到与GTP结合的具有活性的GTP酶。它们已被用于通过*组织化学监测细胞和组织中 G 蛋白的活化和分布。
001. The Scaffold Rho Protein ARH8/
BP1 Synchronizes Rac and Rho Signaling to Facilitate Cell Migration |
002. Downregulation of CYRI-B promotes migration,
invasion and EMT by activating the Rac1-STAT3 pathway in gastric cancer |
003. Loss of cell–cell adhesion triggers
cell migration through Rac1-dependent ROS generation |
004. Catalpol inhibits hepatic stellate
cell activation by reducing the formation and changing the contents of hepatocyte-derived
extracellular vesicles |
005. Cardiac inducing colonies halt
fibroblast activation and induce cardiac/endothelial cells to move and expand
via paracrine **ing |
006. Inhibition of Rac1 attenuates
radiation-induced lung injury while suppresses lung tumor in mice |
007. Smooth muscle Rac1 contributes to
pulmonary hypertension |
008. Rac1 mediates cadherin-11 induced
cellular pathogenic processes in aortic valve calcification |
009. A Portable Controllable Compressive
Stress Device to Monitor Human Breast Cancer Cell Protrusions at Single-Cell
Resolution |
010. Hepatic Ischemia-reperfusion Injury in
Mice was Alleviated by Rac1 Inhibition – More Than Just ROS-inhibition |
011. Targeting the ASMase/S1P pathway
protects from sortilin-evoked vascular damage in hypertension |
012. Planar cell polarity-dependent
asymmetric organization of microtubules for polarized positioning of the
basal body in node cells |
013. Time of Day-Dependent Alteration of
Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats |
014. Transient neuroinflammation following
surgery contributes to long-lasting cognitive decline in elderly rats via
dysfunction of synaptic NMDA receptor |
015. ARHGEF37 overexpression promotes
extravasation and metastasis of hepatocellular carcinoma via directly
activating Cdc42 |
016. Organoid-on-a-chip model of human
ARPKD reveals mechanosensing pathomechanisms for drug discovery |
017. Differential dysregulation of granule
subsets in WASH-deficient neutrophil leukocytes resulting in inflammation |
018. The Pro-Fibrotic Response to Lens
Injury Is Signaled in a PI3K Isoform-Specific Manner |
019. Anti-ANGPTL3-FLD monoclonal antibody
treatment ameliorates podocyte lesions through attenuating mitochondrial
damage |
020. Critical role of mitogen-inducible
gene 6 in restraining endothelial cell permeability to maintain vascular
homeostasis |
021. PTEN Protein Phosphatase Activity Is
Not Required for Tumour Suppression in the Mouse Prostate |
022. Dock4 is required for the maintenance
of cochlear hair cells and hearing function 武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前研发俩种*特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体的信号转导，包括跨膜受体，例如介导味觉、嗅觉和视觉的那些，（2）核糖体的蛋白质生物合成，（3）调节细胞分化、增殖、分裂和运动，（4）蛋白质通过膜的易位，（5）细胞内囊泡的运输，以及囊泡介导的分泌和摄取，通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。 我公司将向你提供以下三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应**型的抗体。 (3) 对 cAMP 和 cGMP 具有**亲和力（*乙酰化）ELISA检测试剂盒。这些产品被将近一千篇**评议的文章所引用。 |
武汉费斯德生物科技有限公司专注于G蛋白活性抗体及试剂盒,非乙酰化CAMP和CGMP试剂,点突变抗体等